Long Term Muscle Culture System

The Long Term Muscle Culture System is primarily designed for studies where the effect of a mechanical , biological or other intervention is monitored over time. Its primary use is intact living muscle preparations. It combines the versatility of the rugged and stable force transducer of the KG series with fast and sensitive force measurements.

KEY FEATURES:

  • Sophisticated cuvette system: Completely closed heat controlled sterilizeable incubation cuvette system. All parts in contact with the incubation medium can be sterilized at 140°C. Small cuvette volume (appr. 1ml). Integrated magnetic stirrer provides optimal oxygen supply. Convenient solution change without opening the cuvette system
  • Special preparation holder for papillary muscle, trabeculae, skeletal and smooth muscle available.
  • Fiber Length precisely adjustable with micrometers on both sides.
  • Mechanically stable platform for combining mechanical & simple optical muscle studies
  • Integrated temperature control adjustable between 30°C and 42°C.
  • Standard equipped with linear motor for muscle length perturbation studies
  • Expandable with a stimulator & tetanizer for intact muscle stimulation
  • Expandable with a photometer for the microscope to allow intracellular calcium studies
  • Field stimulation electrodes available

KEY EXPERIMENTS / MUSCLE Parameters:

1)      Measure intact muscle responses to electrical stimulation or tetanus. Measure myomechanical properties of contracting and relaxing muscle strips. An ergometer can be used to perform after-loaded contractions in heart muscle and to perform eccentric contractions. background information

2)      Twitch amplitude and kinetics analysis, time to peak, (50%) relaxation velocities, starling curve, diastolic force development with Software Muscledata..

3)      A linear motor plus control units can be adapted to measure mechanical muscle properties such as Slack-test, Isotonic release, Constant velocity release, Stretch release, vibration, eccentric and after-loaded contractions (intact muscle) background information

Instrument Control can be via hardware Motor Action Control Panel so you can use your own data acquisition system and software or via our integrated package DAS/MuscleData that controls all hardware and records all muscle data and optical recordings.


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Design & Implementation: Lucy Kuijk.
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